Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters

Bioorg Med Chem Lett. 2002 Mar 25;12(6):845-7. doi: 10.1016/s0960-894x(02)00048-3.

Abstract

Iodinated 3beta-aryltropanes functionalized appropriately at the 2beta-, 8- and aryl positions display selective binding to either the dopamine or serotonin transporters.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Binding Sites
  • Binding, Competitive
  • Carrier Proteins / metabolism*
  • Dopamine / metabolism
  • Dopamine Plasma Membrane Transport Proteins
  • Hydrocarbons, Iodinated / chemical synthesis*
  • Hydrocarbons, Iodinated / chemistry
  • Hydrocarbons, Iodinated / pharmacokinetics
  • Iodine Radioisotopes
  • Membrane Glycoproteins / metabolism*
  • Membrane Transport Proteins / metabolism*
  • Nerve Tissue Proteins*
  • Radiopharmaceuticals / chemical synthesis
  • Serotonin / metabolism
  • Serotonin Plasma Membrane Transport Proteins
  • Structure-Activity Relationship
  • Tropanes / chemical synthesis*
  • Tropanes / chemistry
  • Tropanes / pharmacokinetics

Substances

  • Carrier Proteins
  • Dopamine Plasma Membrane Transport Proteins
  • Hydrocarbons, Iodinated
  • Iodine Radioisotopes
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Radiopharmaceuticals
  • Serotonin Plasma Membrane Transport Proteins
  • Tropanes
  • Serotonin
  • Dopamine